航空发动机复杂扭曲叶片分步电解加工研究

为实现复杂扭曲叶片在较小间隙下的稳定加工,提出了一种分步式电解加工的工艺方法,建立了复杂扭曲叶片小间隙(0.2 mm)和大间隙下(0.5 mm)扭曲流道的流道模型,采用有限元法进行了流场仿真研究,结果表明增加流道间隙可以解决流道中涡流和流场紊乱的问题。开展了复杂扭曲叶片小间隙连续式加工和分步式加工的试验研究。结果表明,采用小间隙连续式加工,当阴极进给至3.8 mm位置时,在叶片排气边靠近叶根流道扭曲处出现短路打火情况;而采用分步式加工方式能够实现加工的顺利进行。     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

Modelling of electron energy absorption and backscattering during EBW

A three-dimensional heat flux model for deep-penetrating electron beam welding (EBW) is established to mathematically describe the physical heat generation process during interaction between electrons and the dynamic molten pool free surface. Monte Carlo method is used to determine the electron-target interaction, and random distribution of initial electrons, progressive trajectory tracing and electron backscattering models are used to describe the spatial distribution of electrons absorption. The model is verified in preset keyholes and applied in the simulation on electron beam welding process, and the calculated bead shape shows a good consistency with experimental results.     

水泥厂堆取料机轨道梁设计优化及安装

正0前言近年来苏州中材建设有限公司承建了多条海外5 000 t/d水泥熟料生产线EPC总承包项目。原燃料堆场多采用圆型堆场或长型堆场,例如400 m长型辅助原料堆场有约1 600 m轨道梁、4 200多支螺栓,直径Φ90 m圆型堆场有约282 m轨道梁、1150支螺栓,合计共有约5 350多支螺栓需要安装,燃料为煤的生产线,工作量更是庞大。堆取料机轨道行程较长,对固定轨道螺栓的安     

15CrMoG钢棒材表面缺陷机理分析和工艺改进

分析得出,棒材表面细小纵裂纹和表面裂口缺陷产生于铸坯加热之前,且与结晶器弯月面保护渣有关。利用Thermo-Calc热力学软件计算15CrMoG钢凝固相变过程,结合亚包晶钢连铸凝固特点综合分析15CrMoG钢棒材表面缺陷的产生原因和产生机理。结果表明:15CrMoG钢在固相线温度附近发生包晶反应L+δ→γ和包晶转变δ→γ,不仅导致初生坯壳生长不均匀,而且加剧P、S元素在凝固前沿的偏析。而初生坯壳不均匀是导致棒材表面缺陷根本原因。棒材表面细小纵裂纹产生于结晶器内坯壳薄弱处,经过二冷和轧制工序在夹杂物和硫偏聚处扩展长大。棒材表面裂口缺陷是初生坯壳不均匀导致结晶器内液面波动大,造成铸坯夹渣所致。通过控制[C]0.16%～0.17%、[S]≤0.005%、保护渣碱度1.2、熔点≥1200℃、粘度≥1.0Pa·s,260 mm×30mm铸坯水量150 m³/h,拉速0.5 m/min等措施,裂纹合格探伤合格率由原45%提高至98%。     

Recent progress of green sorbents-based technologies for low concentration CO2 capture

The increased concentration of CO₂ due to continuous breathing and no discharge of human beings in the manned closed space, like spacecraft and submarines, can be a threat to health and safety. Effective removal of low concentration CO₂ from the manned closed space is essential to meet the requirements of long-term space or deep-sea exploration, which is an international frontier and trend. Ionic liquids (ILs), as a widespread and green solvent, already showed its excellent performance on CO₂ capture and absorption, indicating its potential application in low concentration CO₂ capture. In this review, we first summarized the current methods and strategies for direct capture from low concentration CO₂ in both the atmosphere and manned closed spaces. Then, the multi-scale simulation methods of CO₂ capture by ionic liquids are described in detail, including screening ionic liquids by COSMO-RS methods, capture mechanism by density functional theory and molecular dynamics simulation, and absorption process by computational fluid dynamics simulation. Lastly, some typical IL-based green technologies for low concentration CO₂ capture, such as functionalized ILs, co-solvent systems with ILs, and supported materials based on ILs, are introduced, and analyzed the subtle possibility in manned closed spaces. Finally, we look forward to the technology and development of low concentration CO₂ capture, which can meet the needs of human survival in closed space and proposed that supported materials with ionic liquids have great advantages and infinite possibilities in the vital area.